Mathies Lab

Erik Jensen publishes "A digital microfluidic platform for the automation of quantitative biomolecular assays" in Lab on a Chip.

A digital microfluidic Automaton, based on 2-dimensional microvalve array technology, is developed and optimized for sample processing and analysis. Digital transfer of fluids between microvalves enables precise metering of nanoliter scale sample volumes through programmable valve networks within the array. High level device programming enables rapid automation of diverse assay protocols on a common chip format.

Read the article here.

Chong Fang publishes "Mapping GFP structure evolution during proton transfer with femtosecond Raman spectroscopy" in Nature.

Using Femtosecond Stimulated Raman Spectroscopy, a technique developed in this group, the researchers have elucidated the reason for GFP's high florescence.

Read the article here. Editor's summary here.

Yong Zeng publishes "High-performance single cell genetic analysis using microfluidic emulsion generator arrays" in Analytical Chemistry.

High-throughput single cell analysis technologies hold the key for both statistical characterization of stochastic genetic variation and sensitive detection of rare mutants within large cell populations. The cover shows a microfabricated emulsion generator array device on a 4-inch glass wafer. A compact micropump composed of three coaxial ring-shaped valves drives a high-density array of 96 droplet generators capable of producing 3 x 10^6 nL droplets per hour for high-throughput multiplex genetic analysis of single cells.

Read the article here.