Yong Zeng

Personal Information

Lab Position

Postdoctoral Fellow

Email

yongz [ at ] berkeley.edu

Education

Postdoc. Department of Chemistry,
University of California, Berkeley, 2008-present

Ph.D. Analytical Chemistry,
University of Alberta, 2007

M.S. Analytical Chemistry,
Wuhan University, 2001

B.S. Chemistry,
Wuhan University, 1998

My Research Interests

Research Description

I am working on the development of an ultrahigh-throughput microdroplet generator array system for co-encapsulating single cell and single primer-functionalized bead in each uniform nanolitre-sized droplet for single-cell genetic analysis (SCGA). I am also working with Richard Novak to implement this SCGA system in detecting low-frequency mutations and polymorphisms in cell populations for cancer diagnosis, such as the t(14;18) IgH/Bcl2 translocation.

References

Journal Publications
11. R. Novak,* Y. Zeng,* J. Shuga, G. Venugopalan, D. Fletcher, L. Zhang, M. T. Smith, R. A. Mathies, “Single Cell Multiplex Gene Detection and Sequencing Using Microfluidically-Generated Agarose Emulsions”, Angew. Chem. Int. Ed., 2011, 50, 390–395. (*Equal contribution)
10. E. C. Jensen,* Y. Zeng,* J. K. Kim, R. A. Mathies, “Microvalve Enabled Digital Microfluidic Systems for High Performance Biochemical and Genetic Analysis”, JALA, 2010, 15, 455-463. (*Equal contribution)
9. J. Shuga, Y. Zeng, R. Novak, R. A. Mathies, P. Hainaut, M. T. Smith, “Selected Technologies for Measuring Acquired Genetic Damage in Humans”, Environmental and Molecular Mutagenesis, 2010, 51, 851-870. (Invited review)
8. M. He, J. Bao, Yong Zeng, D. J. Harrison, “Parameters Governing Flow Properties of Porous Monoliths Photopatterned within Microfluidic Channels”, Electrophoresis, 2010, 31, 2422-2428.
7. Yong Zeng, R. Novak, J. Shuga, M. T. Smith, R. A. Mathies, “High-Performance Single Cell Genetic Analysis Using Microfluidic Emulsion Generator Arrays”, Anal. Chem., 2010, 82, 3183-3190. (cover paper)
6. Yong Zeng, Mei He, D. J. Harrison, “Microfluidic Self-Patterning of Large-Scale Crystalline Nanoarrays for High-Throughput Continuous DNA Fractionation”, Angew. Chem. Int. Ed. 2008, 47, 6388-6391.
5. M. He, Yong Zeng, X. J. Sun, D. J. Harrison, “Confinement effects on the morphology of photopatterned porous polymer monoliths for capillary and microchip electrophoresis of proteins”, Electrophoresis, 2008, 29, 2980-2986.
4. Yong Zeng, D. J. Harrison, “Self-Assembled Colloidal Arrays as Three-Dimensional Nanofluidic Sieves for Separation of Biomolecules on Microchips”, Anal. Chem., 2007, 79, 2289-2295. (Highlighted in the Research Profile: “Nanofluidic Sieves Ease Separation Anxiety”, Anal. Chem., 2007, 79, 2611)
3. Yong Zeng, D. J. Harrison, “Confinement Effects on Electromigration of Long DNA Molecules in an Ordered Cavity Array”, Electrophoresis, 2006, 27, 3747-3752.
2. Yong Zeng, H. Chen, D. W. Pang, Z. L. Wang, J. K. Cheng, “Microchip Capillary Electrophoresis with Electrochemical Detection”, Anal. Chem., 2002, 74, 2441-2445.
1. H. Chen, Yong Zeng, B. F. Liu, D. W. Pang, J. K. Cheng, “Influence of Soluble Polymer Polyvinylpyrrolidone on Separation of Small Peptides and Amino Acids by Microchip-Based Capillary Electrophoresis”, Anal. Bioanal. Chem., 2002, 373, 314-317.

Conference Presentations

15. R. Novak, Y. Zeng, J. Shuga, G. Venugopalan, D. Fletcher, L. Zhang, M. T. Smith, R. A. Mathies, “Microdroplet Emulsion Generator Arrays for High-Throughput Single Cell Genetic Variation Analysis” 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2010), Groningen, The Netherlands, Oct. 2010. (Young Researcher Poster Award)
14. Yong Zeng, R. Novak, R. A. Mathies, “High-Performance Single Cell Genetic Analysis Using Microfluidic Emulsion Generator Arrays”, American Chemical Society (ACS) Spring 2010 National Meeting, San Francisco, CA, USA, March, 2010. (Oral)
13. Yong Zeng, R. A. Mathies, “Microfluidic Technologies for Single Cell Genetic and Expression Analysis” Sixth Annual Quantitative PCR Conference, San Diego, CA, USA March 2010. (Invited presentation)
12. R. A. Mathies, E. Jensen, Yong Zeng, “Integrated Microfluidic Systems for High Performance Biochemical and Genetic Analysis”, American Laboratory Association Meeting, Palm Springs, CA, USA, Jan. 2010. (presented by R. A. Mathies)
11. J. Shuga, Yong Zeng, R. Novak, L. Zhang, M. T. Smith, R. A. Mathies, “High-Throughput Single Copy/Cell Detection of Mutations” Biological Response Steering Committee Meeting, Maryland, USA, Jan. 2010. (Poster)
10. Yong Zeng, R. Novak, J. Shuga, N.M. Toriello, N. Thaitrong, P. Kumaresan, C.J. Yang, L. Zhang, M. T. Smith, R. A. Mathies, “Microfluidic Technologies for Single Copy/Cell Genetic Analysis”, QB3/UCSF/UCB Cost Effective Health Care Technology Workshop, San Francisco, USA, June, 2009.
9. Yong Zeng, R. Novak, J. Shuga, P. Kumaresan, L. Zhang, M. T. Smith, R. A. Mathies, “High-Throughput Detection of Mutations in Single Cells” The Genes, Environment and Health Initiative, Exposure Biology 2nd Annual Meeting, Maryland, USA, Jan. 2009. (Poster)
8. Yong Zeng, P. Kumaresan, N.M. Toriello, E.S. Douglas, C.J. Yang, R.G. Blazej, S.A. Cronier, N. Thaitrong. S.C.H. Hsaio, M.B. Francis, C.R. Bertozzi, and R.A. Mathies, “Microfluidic Technologies for Single Cell Genetic and Expression Analysis” 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2007), San Diego, CA, USA, Oct. 2008. (Poster)
7. Neda Nazemifard, Yong Zeng, D.J. Harrison, S. Bhattacharjee, J. Masliyah, “DNA Transport and Fractionation through a Self-Assembled Nanoparticle Array in Presence of Pulsed Electric Field” The 82nd ACS Colloid & Surface Science Symposium, Raleigh, NC, USA, June 2008. (Oral)
6. Yong Zeng, D. J. Harrison, “High-Throughput DNA Microfractionator Using Self-Patterned Large-Scale Crystalline Nanoarrays”, 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2007), Paris, France, Oct. 2007. (Oral)
5. Mei He, Yong Zeng, D. J. Harrison, “Confinement Effect on The Structure of Polymer Monoliths Photopatterned within Microchannels”, 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2007), Paris, France, Oct. 2007. (Poster)
4. Yong Zeng, D. J. Harrison, “On-Chip Biomolecule Separation Using Self-Assembled Colloidal Nanoarrays”, MSB 2007: 21th International Symposium on Microscale Bioseparations, Vancouver, BC, Canada, Jan. 2007. (Oral)
3. Yong Zeng, D. J. Harrison, “Self-Assembled Three-Dimensional Nanofluidic Sieves for Bioseparation”, 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2006), Tokyo, Japan, Nov. 2006, pp. 1020-1022. (Oral)
2. Yong Zeng, D. J. Harrison, “Ordered Nanopore Cavity Array Structured by Colloidal Templating for Electrophoresis of Large DNA Molecules”, 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2005), Boston, MA, USA, Oct. 2005, pp. 494-496. (Oral)
1. Yong Zeng, D. J. Harrison, “Electrophoresis of Single DNA Molecules in an Ordered Nanopore Network Fabricated by Colloidal Templating”, 88th Canadian Chemistry Conference and Exhibition, Saskatoon, SK, Canada, May 2005. (Oral)

History

Member for

2 years 4 weeks